Inclusion Criteria

Study participants must meet all of the criteria below. They may not participate in the study if one or more of these criteria is not met.

  1. Is 35-55 years old.
  2. Receives care within Kalamazoo County and neighboring areas.
  3. Has no known history of coronary artery disease (CAD), peripheral vascular disease (PVD) or stroke.
  4. Answered asymptomatic on WHO Rose Angina Questionnaire.
  5. Has any one of these risk factors for CAD:
    1. Premature Immediate Family History (Male younger than 55, Female younger than 65)
    2. Chronic Smoker, currently smoking at least 1 cigarette per month.
    3. Diabetes Mellitus Type 2.
    4. Any family history of CAD with high cholesterol or hypertension or former smoker.
  6. Doesn’t need a stress test or catherization.
  7. Has signed the informed consent sheet.

Exclusion Criteria

If one or more of these criteria are met, subject cannot participate in study.

  1. Has coronary artery disease
  2. Has had an abnormal stress test in which coronary angiography is recommended.
  3. Unable to walk at least 20 ft. without assistance of a walker or person.
  4. Has a blood infection at time of procedure.
  5. Has uncontrolled hypertension (more than 180 mmHg systolic and more than 110 mmHg diastolic)
  6. Is in need of surgery or has unstable blood pressure.
  7. Has known negative reactions to iodinated contrast media (dye used in CCTA).
  8. Has known negative reactions to beta blockers.
  9. Has known negative reactions to sublingual nitroglycerine
  10. Has history of kidney disease with GFR of 45 or below.
  11. Has history of NICMP.
  12. Has severe systemic disease or illness with life expectancy less than two years.
  13. Is already participating in another study that interferes with this study.
  14. Is pregnant or lactating.
  15. Has known arrhythmias that block ECG triggering.
  16. Has history of a brain tumor, injury, concussion, epilepsy or other seizures, severe liver disease, sickle cell anemia, multiple sclerosis, substance abuse, thyroid disorder, Kahler’s disease, or PCC.